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2.8: Methods for Separating Mixtures

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  • Beginning in the late 1840s, thousands of prospectors rushed to California in search of gold. One of the approaches taken to isolate the gold from the soil was called "panning". To pan, dirt is placed in a pan and covered with water. After mixing thoroughly, the pan is gently swirled to remove dissolved material, while the heavier gold settles to the bottom of the pan. The gold is then separated from the mixture of soil and water.

    Not everyone is out to search for gold (and not many searches will get much gold, either). In a chemical reaction, it is important to isolate the component(s) of interest from other materials, so that they can be further characterized. Studies of biochemical systems, environmental analysis, and pharmaceutical research, among others, may require reliable separation methods. Following are a number of common separation techniques.


    Chromatography is the separation of a mixture by passing it in solution or suspension, or as a vapor (as in gas chromatography), through a medium in which the components move at different rates. Thin-layer chromatography is a special type of chromatography used for separating and identifying mixtures that are or can be colored, especially pigments.


    Distillation is an effective method to separate mixtures that are comprised of two or more pure liquids. Distillation is a purification process where the components of a liquid mixture are vaporized and then condensed and isolated. In simple distillation, a mixture is heated, and the most volatile component vaporizes at the lowest temperature. The vapor passes through a cooled tube (a condenser), where it condenses back into its liquid state. The condensate that is collected is called distillate.

    Distillation apparatus.

    In the figure above, we see several important pieces of equipment. There is a heat source, a test tube with a one-hole stopper attached to a glass elbow, and rubber tubing. The rubber tubing is placed into a collection tube, which is submerged in cold water. There are other more complicated assemblies for distillation that can also be used, especially to separate mixtures which are comprised of pure liquids, with boiling points that are close to one another.


    Evaporation is a technique used to separate out homogeneous mixtures that contain one or more dissolved salts. The method drives off the liquid components from the solid components. The process typically involves heating the mixture until no more liquid remains. Prior to using this method, the mixture should only contain one liquid component, unless it is not important to isolate the liquid components. This is because all liquid components will evaporate over time. The evaporation method is suitable to separate a soluble solid from a liquid.

    In many parts of the world, table salt is obtained from the evaporation of sea water. The heat for the process comes from the sun.

    Once the sea water in these evaporation ponds has evaporated, the salt can be harvested.


    Filtration is a separation method used to separate out pure substances in mixtures comprised of particles—some of which are large enough in size to be captured with a porous material. Particle size can vary considerably, given the type of mixture. For instance, stream water is a mixture that contains naturally occurring biological organisms like bacteria, viruses, and protozoa. Some water filters can filter out bacteria, the length of which are on the order of 1 micron. Other mixtures, like soil, have relatively large particle sizes, which can be filtered through something like a coffee filter.



    • Mixtures can be separated using a variety of techniques.
    • Chromatography involves solvent separation on a solid medium.
    • Distillation takes advantage of differences in boiling points.
    • Evaporation removes a liquid from a solution to leave a solid material.
    • Filtration separates solids of different sizes.

    Explore More

    Use this resource to answer the following questions:

    1. List three methods of separating mixtures.

    2. When is filtration the most efficient method for separation?

    3. When is evaporation the most efficient method for separation?

    4. Compare simple and fractional distillation.

    Contributors and Attributions

    • CK-12 Foundation by Sharon Bewick, Richard Parsons, Therese Forsythe, Shonna Robinson, and Jean Dupon.

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