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1.44: Toxicology

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    1. The dose-response relationship for a toxicant is expressed as:
      1. the level at which all the treated group will die
      2. the level at which several of a treated group will die
      3. the level at which 1% of a treated group will die
      4. a semilogrithmic relationship between effect and level
      5. a linear relationship between effect and level

    The following mechanisms in for the questions listed in Column A are associated with toxic agents. Match the mechanism with the agent in Column B.

    Column A

    1. Irreversible enzyme inhibition
    2. Reversible enzyme inhibition
    3. Hepatic poisoning
    4. Blockage of oxygen transport
    5. Depression of the central nervous system
    6. Damage to DNA and RNA

    Column B

    1. cyanide
    2. acetaminophen
    3. Carcinogens or teratogens
    4. benzodiazepines
    5. salicylates
    6. tylenol
    7. arsenates
    8. opiates
    9. organophosphates

    Match the drug in Column A (questions) with its antidote in Column B.

    Column A

    1. Acetominophen
    2. Opiates
    3. Organophosphates

    Column B

    1. chlorpromazine
    2. methionine
    3. physostigmine
    4. oxygen
    5. sodium nitrate
    6. naloxone
    7. atropine

    Use the following Key to answer Questions 11-12:

    1. 1, 2, and 3 are correct
    2. 1 and 3 are correct
    3. 2 and 4 are correct
    4. 4 only is correct
    5. all are correct
    1. Which of the following statements about poisons are true?
      1. all substances are poisons
      2. poisons differ qualitatively from other compounds
      3. substances taken in sufficient quantities will be poisons
      4. most poisons have antidotes
    2. Which of the following factors can influence toxicity of an agent?
      1. chemical properties
      2. route of administration
      3. duration of exposure
      4. age
    Answer
    1. d (p. 991)
    2. i (p. 999)
    3. g (p. 999)
    4. b (p. 998, 1007)
    5. a (p. 999)
    6. h (p. 997-998)
    7. c (p. 999)
    8. b (p. 1000,1007)
    9. f (p. 1000)
    10. g (p. 1000)
    11. b (p. 991)
    12. e (p. 991-994)

    1.44: Toxicology is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.

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