Reductive Amination
- Page ID
- 42313
Reductive amination is the synthetic protocol in which an aldehyde or a ketone is converted to an amine via an imine.
In the first stage of the procedure, the aldehyde or the ketone is treated with ammonia or a primary amine in the presence of an acid catalyst. An addition-elimination reaction results in an imine. In the second stage, the imine is reduced to the corresponding amine.
eg. 1:
eg. 2:
Contributors
- Gamini Gunawardena from the OChemPal site (Utah Valley University)