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Chemistry LibreTexts

Part IX. Closing Thoughts

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  • For instructors interested in building into their laboratory curriculum a method development exercise based on the use of response surfaces, the following experiments from the Journal of Chemical Education may be of interest:

    “Introduction to the Design and Optimization of Experiments Using Response Surface Methodology. A Gas Chromatography Experiment for the Instrumentation Laboratory,” Lang, P. L.; Miller, B. I.; Nowak, A. T. J. Chem. Educ.200683, 280–282.

    “Experimental Design and Optimization: Application to a Grignard Reaction,” Bouzidi, N.; Gozzi, C. J. Chem. Educ., 2008, 85, 1544–1547.

    “Visualizing the Solute Vaporization Interference in Flame Atomic Absorption Spectroscopy,” Dockery, C. R.; Blew, M. J.; Goode, S. R. J. Chem. Educ., 2008, 85, 854–858.

    “Attaining Optimal Conditions: An Advanced Undergraduate Experiment that Introduces Experimental Design and Optimization,” Van Ryswyk, H.; Van Hecke, G. R. J. Chem. Educ., 1991, 68, 878–882.

    “Optimization of HPLC and GC Separations Using Response Surfaces: Three Experiments for the Instrumental Analysis Laboratory,” Harvey, D. T.; Byerly, S.; Bowman, A.; Tomlin, J. J. Chem. Educ., 1991, 68, 162–168.

    “Central Composite Experimental Designs: Applied to Chemical Systems,” Palasota, J. A.; Deming, S. N. J. Chem. Educ., 1992, 69, 560–563.

    “Mixture Design Experiments Applied to the Formulation of Colorant Solutions,” Gozálvez, J. M.; García-Díaz, J. C. J. Chem. Educ., 2006, 83, 647–650.

    “Experimental Design, Near-Infrared Spectroscopy, and Multivariate Calibration: An Advanced Project in Chemometrics,” J. Chem. Educ., 2012, 89, 1566–1571.

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