Skip to main content
Chemistry LibreTexts

Zaitsev’s Rule

[ "article:topic", "authorname:ggunawardena", "Zaitsev\u2019s Rule" ]
  • Page ID
    42721
  • Zaitsev’s or Saytzev’s (anglicized spelling) rule is an empirical rule used to predict regioselectivity of 1,2-elimination reactions occurring via E1 mechanism or via E2 mechanism.  It states that in a regioselective E1 or E2 reaction the major product is the more stable alkene, i.e., the alkene with the more highly substituted double bond.

    eg:

     

     

    E1 reaction always follow Zaitsev’s rule; with E2 reactions, there are exceptions (see antiperiplanar).

    see also Hofmann rule