11.03 Modeling Replication<p><img src="$IMS-CC-FILEBASE$../resources/dnarepmodel_573c8643bbe61.jpg" width="324" height="243" style="float: right; margin: 10px;" id="tme_imgModEnabled" title="" /></p>
<p style="line-height: 16.8px;"><span style="font-size: 16px;">Use two ziploc plastic bags to model how complementary strands of DNA attach to template strands during replication.</span></p>
<p style="line-height: 16.8px;"><span style="font-size: 16px;">Materials:</span></p>
<ul style="line-height: 16.8px;">
<li><span style="font-size: 16px; line-height: 22.4px;">2 ziploc bags</span></li>
<li><span style="font-size: 16px; line-height: 22.4px;">scissors</span></li>
</ul>
<p style="line-height: 16.8px;"><span style="font-size: 16px; line-height: 22.4px;">Procedure:</span></p>
<ul style="line-height: 16.8px;">
<li><span style="font-size: 16px; line-height: 22.4px;">Cut the sliding sippers off both bags</span></li>
<li><span style="font-size: 16px; line-height: 22.4px;">One zipper represents the template strands of a DNA molecule</span></li>
<li><span style="font-size: 16px; line-height: 22.4px;">Cut the other zipper into four smaller pieces and unzip each of them. These represent free nucleotides.</span></li>
<li><span style="font-size: 16px; line-height: 22.4px;">Use the pieces to model replication as demonstrated in the animation<a href="http://my.hrw.com/content/hmof/science/high_school_sci/na/gr9-12/hmd_bio_9780547688442_/dlo/animatedbiology/b08_03as91/index.html">Replicating DNA</a>.</span></li>
</ul>
<p><span style="font-size: 16px; line-height: 22.4px;">Analysis:</span></p>
<ul>
<li><span style="font-size: 16px; line-height: 22.4px;">What are the limitations of this model?</span></li>
</ul>