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Lab Appendix

Introduction/Purpose

Cyclic voltammetry is one of the most effective electroanalytical methods for the elucidation of the mechanism of the electrode processes. Catechol is an important neurotransmitter secreted in the brain and controls locomotion. Many mental and behavioral disorders such as Alzheimer’s disease, Parkinson’s disease, eating disorders, epilepsy, amphetamine addiction and cocaine addiction have been associated with altered levels of these neurotransmitters such as catechol in the brain. The goal of this lab is to develop two different types of electrochemical sensors; 1) a poly (3-methylthiophene) sonogel-carbon electrode and, 2) a sonogel-carbon titanium oxide (SGC/TiO2) to detect catechol by cyclic voltammetry in the presence of a common interferent ascorbic acid. Determine which modified sensor electrode developed would be the best to detect neurotransmitters from the cyclic voltammogram results.

References/Supplemental Readings Suggested

  1. D.A. Douglas, and D.M. West, Fundamentals of Analytical Chemistry, 4th edition, Saunders; Philadelphia, 1982.
  2. P.T. Kissinger and W.R. Heineman, J. Chem, Ed., 60, 702 (1983).
  3. J.J.. Van Benschoten, J.Y. Lewis, W.R. Heineman, D.A. Roston, and P.T. Kisssinger, J. .Chem. Ed., 60, 772 (1983).
  4. W.R. Heineman and P.T. Kissinger in “Laboratory Techniques in Electroanalytical Chemistry,” Dekker, New York, 1984.
  5. A.J, Bard, and L. R. Faulkner, “Electochemical Methods”, Wiley, New York, 1980.
  6. H. Zhang, S.K. Lunsford, I. Marawi, J.F. Rubinson, and H.B. Mark, Jr., J. Electroanal. Chem., 1997, 424, 101-111.